Showing posts with label allergy. Show all posts
Showing posts with label allergy. Show all posts

Saturday, February 23, 2008

How is food allergy diagnosed?

The diagnosis of food allergy is often based more on a careful evaluation of the patient than on laboratory tests. A person's history and symptoms may have characteristic features and lead to the recognition of food allergy when other conditions which cause similar symptoms have been excluded. To confirm the diagnosis, the patient will be put on a diet which excludes the suspected food or foods. If the symptoms disappear, the food will be reintroduced in order to confirm the diagnosis. Skin tests and a test called RAST (which detects circulating IgE antibodies) are sometimes helpful, especially in younger children. Unfortunately they are far from being totally accurate as diagnostic aids.

Diet Start

There are two major problems in identifying an allergenic food. Firstly, patients may react to not one but several different foods and secondly, the foods they eat may contain a wide range of allergenic ingredients. Bread, for example, may contain wheat, soya, yeast and milk - all of which are potential allergens. Ideally, to get around these problems an `exclusion diet' consisting only of water and a mixture of basic nutrients, should be used for diagnosis. The major drawback is that a diet like this could rapidly lead to malnutrition, especially in babies.

Many specialists prefer to use a so-called `oligoallergenic diet' (see below), which consists of well-defined unprocessed foods that generally produce few allergic reactions. Patients are put on this diet for a number of weeks and if their symptoms improve, they can gradually reintroduce foods one at a time, while watching for the reappearance of symptoms. As tell-tale reactions occur, the responsible food is recognised and eliminated. Since children tend to outgrow their food allergies, the offending food may be reintroduced each year to see whether the child has developed a tolerance to it. Very impressive results have been obtained in treating two common allergic conditions - atopic eczema and migraine - using oligoallergenic diets.

Oligoallergenic diets used to confirm the presence of food allergy

Diet 1 Diet 2

Stewed lamb Turkey

Rice and rice flour Potatoes and potato

Cabbage Carrots

Sweet potato Apples/pears

Milk-free margarine Olive oil

Milk substitute Soya milk

The 'double-blind challenge test'

Some authorities believe that the only way to diagnose food allergy is to use what is known as the 'double-blind challenge test'. In this test, dried foods in powder form are put into opaque capsules. Neither the doctor nor the patient must know what food is contained in the capsules. Patients are observed for up to 72 hours after taking the capsule and careful observation is made of any occurrence of symptoms following each 'challenge'. The major drawback of this method is that it bypasses the mouth, where many symptoms may begin. It is also not possible to use the test in babies and it is a very time-consuming procedure.

Thursday, February 21, 2008

The symptoms of food allergy

If you have ever seen a victim of true food allergy after he or she has eaten an offending food, you will know that the reactions can be alarming! The lips swell up almost instantly and an itchy, raised red rash develops along with welts around the mouth. Sometimes the mouth becomes intensely itchy and the uvula (the small tongue at the back of the throat) may become swollen. The foods which most often cause this kind of reaction are eggs, nuts, shellfish, citru fruits and berries. Reactions in the lower part of the digestive tract take a little longer to develop but nausea and vomiting - often accompanied by sudden severe diarrhoea (sometimes with blood in the stools) - may occur within 30 minutes of eating seafood or eggs. This reaction may be followed by flushing, headaches, itching and palpitations which usually disappear after 2-4 hours. All in all, it can be a very unpleasant business!

Highly allergic people should carry an adrenaline inhaler with them at all times, but especially when eating out. If they feel an allergic reaction starting up, they should immediately take in between 3 and 6 puffs of the inhaler. This will prevent any tightness and swelling occurring in the throat. Immediately thereafter a rapidly acting antihistamine (such as Phenergan) 25mg tablet should be swallowed. In virtually all cases, this on-the-spot treatment will enable the affected person to reach medical attention in good time.

Diet Start

Foods may produce allergic reactions in other organs as well. For example, some people can have asthma attacks which may be just as severe as reactions caused by inhaling allergens such as dust or pollens. Allergy to foods may also worsen an existing allergic rash (urticaria) in other parts of the body. In one hospital study in Europe330 patients with recurrent urticaria (also known as hives or nettle rash) were asked what made their condition worse. Foods were said to worsen their skin rash in 30% of cases and 18% thought that drinks did the same. Fruits: vegetables, nuts and fish were the worst offenders.

The best way of looking at this aspect of food allergy is to divide the symptoms that occur into two groups - those that affect the digestive tract (by far the most common) and those that affect other parts of the body. It is important to stress that these symptoms are much more common in young infants and toddlers under 2 years of age than in older children and adults. In fact, there are few examples of food allergy persisting from infancy or early childhood into adult life and the vast majority of babies who are allergic to some foods outgrow their early sensitivity as their bowel matures.

Digestive symptoms

The immediate reactions which occur on contact with an allergenicfood have been discussed above, as have the other common reactions such as vomiting, diarrhoea, nausea and abdominal pain.

In studies on babies in London, doctors were struck by the fact that there seemed to be a link between putting the infants onto artificial feeds and the onset of colic and diarrhoea. It appeared to be mainly the large bowel that was affected and if the babies were taken off these feeds, their colitis (inflammation of the bowel) cleared rapidly. It was found that the major cause of the problem was cow's milk, though some of the babies had reactions to soya and beef proteins. To find out what was happening, a series of studies were done, using a tube with several well-positioned reflecting optics which allowed the inside of the large bowel to be seen clearly. What this showed was that there was noticeable inflammation of the wall of the colon, which disappeared when the offending food was withdrawn.

Food intolerance appears to be closely linked with the Irritable Bowel Syndrome (IBS) or 'spastic colon' which occurs in adults. In this uncomfortable condition, abdominal pain is accompanied by diarrhoea or constipation. In one research project 21 sufferers from IBS were put onto what is known as an 'elimination diet', consisting only of meat, fruit and water. Fourteen of them found that their symptoms cleared and wheat was identified as the most common cause of symptoms. Maize and dairy products were next on the list.

Reactions to food chemicals

In addition to chemicals which occur naturally in foods (for example, caffeine in coffee), there are numerous others which may be incorporated - either directly or indirectly - into food during the growing, storage or processing stages. These chemicals include flavouring, colourants and preservatives. The first two are the most common - because of their very wide distribution in foods, beverages and pharmaceutical products, practically everyone has some daily contact with one or more flavouring and colourant. However, the consumer is often surprised to learn that an everday food product contains either a synthetic colour or flavour or both.

In many cases the foods are those especially designed for children, for example sweets and various breakfast foods. Tartrazine is the most common colouring agent used and is found in a wide range of foods, beverages and medicines. The adverse responses to it are similar to those caused by aspirin and can include very severe reactions. Most commonly, it causes urticaria, asthma, nasal discharge and itching. The flavour-enhancer monosodium glutamate (MSG) is usually found in prepared meats, meat extracts and in Chinese food. People who are sensitive to MSG may have a reaction known as the `Chinese Restaurant Syndrome' after eating foods containing the offending compound. Sweating, a feeling of weakness and a tight feeling in the chest are the symptoms.

All this means that people who are sensitive to certain chemicals should be extra careful about reading all food labels carefully and should avoid those foods and drinks which contain possible problem causers. However, it is important to emphasise that naturally occurring chemical substances - such as caffeine in tea, coffee and cola drinks and theobromine in chocolate - may also have adverse effects such as insomnia, restlessness, abdominal pain and nausea in sensitive people. No additives are responsible for these reactions.

What is true food allergy?

It is important to stress at the outset that contrary to popular belief, true food allergy is not very common. Actual figures for the number of people affected are difficult to estimate, but in general it is thought that no more than between 1 and 4% of the population suffers from a definite food allergy. Interestingly, true food allergies are usually (but not always) seen in people who also have one of the other common allergic conditions, such as hay fever or asthma. Obviously many more than 4% of the population think that they have a food allergy but several careful studies suggest that as many as half of these patients have no allergic symptoms at all. However, they are often so firmly convinced of their allergy that it is difficult for a doctor to persuade them otherwise.

So how do we pinpoint true food allergy? To begin with, we have to look carefully at the mechanisms and symptoms involved.

Diet Start

How do food allergies work?

Studies of food allergy and food intolerance have always been linked and until recently, most attempts to find out how they worked concentrated on the immune system. The root cause of classical or true allergies - including those to food - is the production of Immunoglobulin-E (IgE) antibodies to the offending molecule or allergen (a substance which causes an allergic reaction). IgE is an antibody which normally does the job of protecting the body against parasite infestation, but in allergic people this mechanism has gone awry. When this happens, instead of having a protective role like that of other antibodies, IgE may produce harmful effects in the body. Abnormal amounts of it are produced in response to protein substances which are completely harmless to non-allergic people. IgE binds to cells rich in chemical substances, known as 'mast' cells.

Once an allergen reacts with the IgE molecule, a complex set of biochemical reactions is set in motion and as a result potent chemicals 4such as histamine, serotonin and prostaglandins are released into the body. These are what cause the intense itching, swelling and inflammation. A more serious effect occurs when really large amounts of these chemicals are released. They enter the circulation system,causing capillaries to enlarge and become more permeable, which in turn results in a drop in blood pressure. This reaction - known as anaphylaxis - may be fatal. Laboratory tests in people who have true food allergy show high levels of IgE, but this is not the case in food intolerance. In fact, the involvement of IgE is what makes the crucial distinction between the two.

The specific area where IgE is important is in the wall of the digestive tract. When an allergic person eats an offending food it could combine with IgE in the tract and set off local inflammation, which in turn makes the wall of the tract more permeable and allows undigested food molecules to get through. Once absorbed, these molecules can cause a whole range of symptoms.

Several recent studies have shown that patients with food allergy tend to have 'leakier' digestive tracts than do healthy people, although this is not always the case. When food molecules do enter the blood they usually form what are termed 'circulating immune complexes' (CICs) with antibodies. These CICs may cause inflammation and could account for the joint pains and migraine which some patients sufferfrom.

IgE and CICs are not the only immune pathways involved in food allergy. Another possible mechanism is via lymphokines' or `cytokines', which are hormone-like substances that form a communication link between different cells in the immune system. In the case of food allergy, an abnormal immune response to food molecules could lead to the release of lymphokines, followed by unpleasant symptoms such as headache, lethargy, dizziness, joint pains and nausea. Other factors, such as the incomplete digestion of particular food proteins, or certain enzyme deficiencies, may also be relevant in allergic people.

Experts believe that at least two of the defects mentioned above, plus certain environmental triggers, are necessary for the symptoms of food allergy to appear. In other words, the theory is that a combination of several factors could be responsible. If this is so, it could explain why no two victims of food allergy seem to have the same symptoms.

... andjoyohoxing